DogSource: Plumb's
13.75 mg/kg · every 12 h
Antibiotic Therapy
Amoxicillin/Clavulanate
Beta-lactamase-inhibitor-potentiated aminopenicillin · bactericidal (cell-wall synthesis inhibitor)
Species: Dogs & Cats11 dose protocols9 dosage forms
This page is a calculation and educational reference for veterinarians and veterinary students. It does not replace examination, culture and susceptibility testing, clinical judgment, or the attending veterinarian's final decision.
Drug overview
Beta-lactamase-inhibitor-potentiated aminopenicillin · bactericidal (cell-wall synthesis inhibitor)
General dose: 12.5 mg/kg PO · every 12 hSource: Plumb's
Spectrum of activity
A broad-spectrum, bactericidal aminopenicillin; adding clavulanic acid (a beta-lactamase inhibitor) makes it active against beta-lactamase-positive staphylococci and anaerobes (including Bacteroides). Its spectrum covers Gram-positives (staphylococci, streptococci, enterococci, Listeria, Actinomyces), many Gram-negatives (Pasteurella, E. coli, Proteus, Haemophilus) and spirochetes (Borrelia of Lyme disease, Leptospira). But it has no activity against Pseudomonas, Enterobacter, Serratia and methicillin-resistant staph (MRSA/MRSP); and because its mechanism is cell-wall inhibition, it has no effect on cell-wall-free (Mycoplasma) or intracellular (Rickettsia, Ehrlichia, Chlamydia) bacteria.
Veterinary uses and doses
General (susceptible) infection
CatSource: Plumb's
Cat: 12.5 mg/kg · every 12 h
Urinary tract infection (UTI)
DogSource: ISCAID 2019
12.5 mg/kg · every 12 h · 3–5 days
Clinical note: For sporadic cystitis, plain amoxicillin is first-line (ISCAID 2019); reserve co-amoxiclav for recurrent/complicated infection or beta-lactamase-producing bacteria.
CatSource: ISCAID 2019
Cat: 10–20 mg/kg · every 12 h · 3–5 days
Clinical note: For sporadic cystitis, plain amoxicillin is first-line and co-amoxiclav is reserved for recurrent/complicated or beta-lactamase-positive cases (ISCAID 2019). In cats most lower-urinary signs are idiopathic (FIC) and non-infectious — confirm infection by culture before giving an antibiotic.
Skin & soft tissue
DogSource: Plumb's
Soft tissue/skin: 12.5 mg/kg · every 12 h · 5–7 days
DogSource: Plumb's
Deep pyoderma: 12.5 mg/kg · every 12 h · 14–120 days
DogSource: Aucoin 2002
Non-superficial pyoderma: 10–25 mg/kg · every 12 h · 3–6 weeks
Clinical note: Maximum 650 mg per dose. If no response by the end of the first week, increase to three times daily; and if there is still no response by the end of the second week, stop treatment.
DogSource: Hillier 2006
Recurrent pyoderma: 13.75–22 mg/kg · every 8–12 h
CatSource: Greene 2006
Cat: 10–20 mg/kg · every 12 h · 5–7 days
Sepsis / bacteremia
DogSource: Plumb's
Bacteremia (oral step-down): 22 mg/kg · every 8–12 h · 7 days
Clinical note: ⚠️ Active sepsis/bacteremia requires initial intravenous therapy. Oral co-amoxiclav is not adequate for a septic patient; this dose is only for oral step-down after the patient is stabilized.
CatSource: Greene 2006
Cat — bacteremia/pneumonia (oral step-down): 10–20 mg/kg · every 8 h · 7–10 days
Clinical note: ⚠️ Active sepsis/bacteremia requires initial intravenous therapy. Oral co-amoxiclav is not adequate for a septic patient; this dose is only for oral step-down after the patient is stabilized.
Dosage forms
- Suspension 156 mg/5 mL (125+31)
- Suspension 228 mg/5 mL (200+28)
- Suspension 312 mg/5 mL (250+62)
- Suspension 457 mg/5 mL (400+57)
- Suspension 643 mg/5 mL (600+43)
- Tablet 62.5 mg (50+12.5)
- Tablet 375 mg (250+125)
- Tablet 625 mg (500+125)
- Tablet 1000 mg (875+125)
Safety and clinical notes
- ⚠️ All doses are expressed as the combined amoxicillin + clavulanic acid amount; tablet and suspension strengths are also the combined amount.
- Contraindicated in penicillin allergy; cross-reactivity with cephalosporins and carbapenems is possible.
- Never give to rabbits, guinea pigs, chinchillas or hamsters — risk of fatal enteritis and clostridial enterotoxemia (it is safe in dogs and cats).
- The most common adverse effects are GI (anorexia, vomiting, diarrhea); giving it with food can help.
- In septicemia or shock, oral absorption is reduced; an injectable form is preferred in those cases.
- No activity against Pseudomonas, Enterobacter, Serratia and methicillin-resistant staph (MRSA/MRSP), nor against Mycoplasma and intracellular bacteria (Rickettsia, Chlamydia).
- The amoxicillin:clavulanate ratio varies in human products (2:1 to 7:1); veterinary products typically have a 4:1 ratio.
- Considered relatively safe in pregnancy (class A in dogs and cats).
Cited sources
- Plumb's
- ISCAID 2019
- Aucoin 2002
- Hillier 2006
- Greene 2006
Calculate a weight-based dose
Drug-data last updated: